Six members of a media company go on a weekend business retreat at an isolated lodge in the woods. When one of the members goes missing, they discover that the lodge was formerly a private mental institution that had been shut down after allegations of devious misconduct. One by one, they fall victim to the dark secrets buried at the lodge.

When two freshmen pledges are accepted into the biggest party frat on campus (ALPHA HOUSE), they think they have it all. That is, until the assistant dean forces the Alphas to share their house with a sorority or face expulsion from school. Not wanting to see their lifelong dream of becoming Alphas destroyed, the pledges convince the other members of the house to take back what's theirs, waging an epic battle of the sexes to fight for their right to party.